In previous courses in the Specialization, we have discussed how to sequence and compare genomes. This course will cover advanced topics in finding mutations lurking within DNA and proteins.
In the first half of the course, we would like to ask how an individual's genome differs from the "reference genome" of the species. Our goal is to take small fragments of DNA from the individual and "map" them to the reference genome. We will see that the combinatorial pattern matching algorithms solving this problem are elegant and extremely efficient, requiring a surprisingly small amount of runtime and memory.
In the second half of the course, we will learn how to identify the function of a protein even if it has been bombarded by so many mutations compared to similar proteins with known functions that it has become barely recognizable. This is the case, for example, in HIV studies, since the virus often mutates so quickly that researchers can struggle to study it. The approach we will use is based on a powerful machine learning tool called a hidden Markov model.
Finally, you will learn how to apply popular bioinformatics software tools applying hidden Markov models to compare a protein against a related family of proteins.
4.6
74 Ratings
Free
per course
Incentives
Shareable Certificate
100% online
Course 6 of 7 in the
Flexible deadlines
Beginner Level
Approx. 21 hours to complete
English
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FAQs About "Finding Mutations in DNA and Proteins (Bioinformatics VI)"
Is the online course "Finding Mutations in DNA and Proteins (Bioinformatics VI)" free?
Yes, "Finding Mutations in DNA and Proteins (Bioinformatics VI)" is a free online course offered on the online classes platform Coursera
Is "Finding Mutations in DNA and Proteins (Bioinformatics VI)" an online course worth taking?
7 students from the online classes platform Coursera have given an average rating of 4.6 to the online "Finding Mutations in DNA and Proteins (Bioinformatics VI)" and at least 6980 have completed this online training.
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